Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 10/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277022 | 1.00 | NISCH (0.49) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL29445153 | 0.88 | NISCH (0.51) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL24277095 | 0.88 | NISCH (0.51) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL24277259 | 0.88 | NISCH (0.51) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL29445034 | 0.87 | NISCH (0.44) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL24276889 | 0.87 | NISCH (0.44) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL29445026 | 0.85 | NISCH (0.48) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL24277031 | 0.85 | NISCH (0.48) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL24277246 | 0.79 | NISCH (0.47) | NISCHMAOAMAOBADRA1AADRA1B | |
| SCHEMBL29445085 | 0.79 | NISCH (0.47) | NISCHMAOAMAOBADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210703-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | Expansion Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022055922-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | EXPANSION THERAPEUTICS, INC. (US) | 2022-03-17 | — | — | WO | disclosed |