Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 20/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710190 | 0.84 | BDKRB2 (0.55) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL2939461 | 0.80 | BDKRB2 (0.58) | BDKRB2 | |
| SCHEMBL1563891 | 0.79 | BDKRB2 (0.68) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL2939769 | 0.74 | BDKRB2 (0.57) | BDKRB2 | |
| SCHEMBL2940233 | 0.74 | BDKRB2 (0.59) | BDKRB2CYP3A4 | |
| SCHEMBL1564395 | 0.74 | BDKRB2 (0.87) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL13146279 | 0.73 | BDKRB2 (0.62) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL2946065 | 0.73 | BDKRB2 (0.59) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL13146140 | 0.72 | BDKRB2 (0.69) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL1563164 | 0.71 | BDKRB2 (1.00) | BDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144897-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | Jerini AG (DE) | 2010-01-20 | — | — | EP | claimed |
| WO-2008116620-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2008-10-02 | — | — | WO | claimed |
| EP-2144897-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | Jerini AG (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008116620-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2008-10-02 | — | — | WO | disclosed |