Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ATF4 | P18848 | 4/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22397109 | 1.00 | ADAMTS5 (0.52) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL3353068 | 1.00 | ADAMTS5 (0.52) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL21819338 | 1.00 | ADAMTS5 (0.52) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL22617491 | 0.98 | ADAMTS5 (0.51) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL22617490 | 0.98 | ADAMTS5 (0.51) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL24997390 | 0.88 | ADAMTS5 (0.49) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL29447045 | 0.88 | POLB (0.44) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL22777699 | 0.88 | POLB (0.44) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL30054581 | 0.88 | ADAMTS5 (0.49) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL15148439 | 0.82 | KMT2A (0.68) | ADAMTS5KMT2AHPGDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212902-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3983378-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2022-04-20 | — | — | EP | disclosed |
| CN-114206829-A | Integrated stress response pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| EP-3962899-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |