Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.73 |
| ▸ | PPARG | P37231 | 2/20 | 0.70 |
| ▸ | BID | P55957 | 6/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.62 |
| ▸ | BAK1 | Q16611 | 5/20 | 0.62 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.62 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.62 |
| ▸ | EP300 | Q09472 | 2/20 | 0.62 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.62 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.62 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.62 |
| ▸ | F7 | P08709 | 3/20 | 0.54 |
| ▸ | F3 | P13726 | 3/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ECE1 | P42892 | 1/20 | 0.54 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945954 | 0.88 | PPARA (0.56) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL489605 | 0.87 | PPARA (0.55) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL2940835 | 0.85 | PPARA (1.00) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL18030237 | 0.85 | PPARA (1.00) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL2942131 | 0.83 | PPARA (0.77) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL2948111 | 0.82 | PPARA (0.75) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL3181471 | 0.82 | PPARA (1.00) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL17669149 | 0.80 | HTT (0.48) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL11327036 | 0.79 | PPARA (0.89) | PPARAPPARGBIDMCL1BCL2L1 | |
| SCHEMBL27147047 | 0.78 | PPARA (0.85) | PPARAPPARGBIDMCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470108-B1 | 1,4-DIHYDROPYRIDINE AND PYRIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENT RES FOUNDATION (IN) | 2016-08-24 | — | — | EP | disclosed |
| EP-1515723-B1 | SUBSTITUTED DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENT RES FOUNDATION (IN) | 2014-02-12 | — | — | EP | disclosed |
| EP-1542683-B1 | CALCIUM CHANNEL BLOCKERS | DIAKRON PHARMACEUTICALS INC (US) | 2013-01-09 | — | — | EP | disclosed |
| CN-1823041-B | 1, 4-dihydropyridine and pyridine compounds as calcium channel blockers | VITTAL MALLYA SCIENT RES FOUND | 2013-01-02 | — | — | CN | disclosed |
| US-7750047-B2 | Modulators (inhibitors/activators) of histone acetyltransferases | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2010-07-06 | — | — | US | disclosed |
| US-20090076155-A1 | MODULATORS (INHIBITORS/ACTIVATORS) OF HISTONE ACETYLTRANSFERASES | KUNDU TAPAS KUMAR | 2009-03-19 | — | — | US | disclosed |
| US-7332629-B2 | Modulators (inhibitors/activators) of histone acetyltransferases | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2008-02-19 | — | — | US | disclosed |
| CN-1823041-A | 1, 4-dihydropyridine and pyridine compounds as calcium channel blockers | VITTAL MALLYA SCIENT RES FOUND (IN) | 2006-08-23 | — | — | CN | disclosed |
| US-20060167107-A1 | Modulators (inhibitors/ activators) of histone acetyltransferases | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2006-07-27 | — | — | US | disclosed |
| EP-1590318-A2 | MODULATORS (INHIBITORS/ACTIVATORS) OF HISTONE ACETYLTRANSFERASES | Jawaharlal Nehru Centre For Advanced Scientific Research (IN) | 2005-11-02 | — | — | EP | disclosed |
| EP-1542683-A2 | CALCIUM CHANNEL BLOCKERS | Diakron Pharmaceuticals, Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1515723-A2 | SUBSTITUTED DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) | 2005-03-23 | — | — | EP | disclosed |
| EP-1470108-A1 | 1,4-DIHYDROPYRIDINE AND PYRIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2004053140-A2 | MODULATORS (INHIBITORS/ACTIVATORS) OF HISTONE ACETYLTRANSFERASES | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004024153-A2 | CALCIUM CHANNEL BLOCKERS | DIAKRON PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2003105854-A2 | SUBSTITUTED DIHYDROPYRIMIDINES, DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) | 2003-12-24 | — | — | WO | disclosed |
| WO-2003062201-A1 | 1,4-DIHYDROPYRIDINE AND PYRIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167107-A1 | Modulators (inhibitors/ activators) of histone acetyltransferases | EP300, HDAC1, KAT2A | PPARA 1402/4885PPARG 1175/4885BID 2395/4885 |
| US-20090076155-A1 | MODULATORS (INHIBITORS/ACTIVATORS) OF HISTONE ACETYLTRANSFERASES | KAT2A, HDAC5, HAT1 | PPARA 164/4885PPARG 161/4885BID 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.