Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918070 | 0.92 | ALDH1A1 (0.66) | ALDH1A1POLBKDM4ETP53HPGD | |
| SCHEMBL14096087 | 0.87 | ALDH1A1 (0.68) | ALDH1A1TP53HPGDSMN1; SMN2AOC3 | |
| SCHEMBL2919490 | 0.84 | ALDH1A1 (0.66) | ALDH1A1POLBKDM4ETP53HPGD | |
| SCHEMBL2918585 | 0.81 | ALDH1A1 (0.65) | ALDH1A1POLBHPGDSMN1; SMN2LMNA | |
| SCHEMBL2919475 | 0.79 | ALDH1A1 (0.55) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2910455 | 0.78 | ALDH1A1 (0.63) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2912174 | 0.78 | ALDH1A1 (0.62) | ALDH1A1POLBHPGDSMN1; SMN2LMNA | |
| SCHEMBL2916209 | 0.76 | ALDH1A1 (0.55) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL2916577 | 0.74 | ALDH1A1 (0.58) | ALDH1A1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL2916583 | 0.74 | ALDH1A1 (0.52) | ALDH1A1POLBHPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709047-B1 | AZABENZOFURAN SUBSTITUTED THIOUREAS AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2010-09-01 | — | — | EP | claimed |