Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.80 |
| ▸ | CA4 | P22748 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27541865 | 1.00 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL135062 | 0.95 | CA1 (0.89) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL29128984 | 0.95 | CA1 (0.89) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL28782721 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL8105341 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL25312642 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL29140463 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL31325555 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL9468146 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL28874166 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3730502-B1 | SYNTHESIS AND APPLICATION OF OXASPIROCYCLODIPHOSPHINE LIGAND | SHENZHEN CATALYS TECH CO LTD (CN) | 2024-10-02 | — | — | EP | claimed |
| US-12071444-B2 | Synthesis and use of oxa-spirodiphosphine ligand | SHENZHEN CATALYS TECHNOLOGY CO., LTD (CN) | 2024-08-27 | — | — | US | claimed |
| US-20220185835-A1 | SYNTHESIS AND USE OF OXA-SPIRODIPHOSPHINE LIGAND | SHENZHEN CATALYS TECHNOLOGY CO., LTD (CN) | 2022-06-16 | — | — | US | claimed |
| WO-2024222481-A1 | PREPARATION METHOD FOR AND USE OF OXASPIRO DIPHOSPHINE LIGAND | 凯特立斯（深圳）科技有限公司 | 2024-10-31 | — | — | WO | disclosed |
| EP-3730502-B1 | SYNTHESIS AND APPLICATION OF OXASPIROCYCLODIPHOSPHINE LIGAND | SHENZHEN CATALYS TECH CO LTD (CN) | 2024-10-02 | — | — | EP | disclosed |
| US-12071444-B2 | Synthesis and use of oxa-spirodiphosphine ligand | SHENZHEN CATALYS TECHNOLOGY CO., LTD (CN) | 2024-08-27 | — | — | US | disclosed |
| US-20220185835-A1 | SYNTHESIS AND USE OF OXA-SPIRODIPHOSPHINE LIGAND | SHENZHEN CATALYS TECHNOLOGY CO., LTD (CN) | 2022-06-16 | — | — | US | disclosed |
| US-11299507-B2 | Synthesis and use of oxa-spirodiphosphine ligand | SHENZHEN CATALYS TECHNOLOGY CO., LTD. (CN) | 2022-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185835-A1 | SYNTHESIS AND USE OF OXA-SPIRODIPHOSPHINE LIGAND | OXER1, OXGR1, ICOSLG | CA1 1174/4885CA4 602/4885LMNA 4109/4885 |
| US-12071444-B2 | Synthesis and use of oxa-spirodiphosphine ligand | OXER1, OXGR1, ICOSLG | CA1 1174/4885CA4 602/4885LMNA 4109/4885 |
| US-11299507-B2 | Synthesis and use of oxa-spirodiphosphine ligand | OXER1, OXGR1, FOXO1 | CA1 1372/4885CA4 591/4885LMNA 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.