FOXO1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4912795	0.51	13/20
SCHEMBL4910663	0.55	11/20
SCHEMBL4923424	0.52	11/20
SCHEMBL4917967	0.50	11/20
SCHEMBL4919221	0.46	11/20
SCHEMBL4921980	0.44	11/20
SCHEMBL4911616	0.57	10/20
SCHEMBL5952761	0.55	10/20
SCHEMBL4910701	0.52	10/20
SCHEMBL4915042	0.51	10/20
SCHEMBL4923160	0.48	10/20
SCHEMBL4913053	0.52	9/20
SCHEMBL4919646	0.64	8/20
SCHEMBL4923449	0.54	8/20
SCHEMBL4919875	0.53	7/20
SCHEMBL4921761	0.46	7/20
SCHEMBL2740087	0.54	5/20
SCHEMBL4919195	0.47	5/20
SCHEMBL8302941	0.56	4/20
SCHEMBL1250628	0.45	4/20

Clinical trials — most relevant to FOXO1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients	PHASE4	UNKNOWN
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Effects of Ipragliflozin on Excessive Fat in Type 2 Diabetes Patients With Non-alcoholic Fatty Liver Disease Treated With Metformin and Pioglitazone	PHASE4	COMPLETED
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.	PHASE3	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome	PHASE2	COMPLETED
Blood Flow Restriction Training in Chronic Heart Failure: an Effective Training Strategy?	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
FoxO3a and PU.1 in Acute Lymphoblastic Leukemia	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone.	nan	COMPLETED
Can Dormant Perimenopausal Ovarian Follicles Become FSH Responsive?	nan	UNKNOWN
Expression of Longevity Genes in Response to Extended Fasting	nan	COMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Research on the Nature, Diagnosis, and Treatment of Obesity and Diabetes	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Molecular Pathways Related to Short-term Fasting Response	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee	nan	COMPLETED
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis	nan	RECRUITING
Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance	nan	COMPLETED
Nasturtium (Tropaeolum Majus L) Intake and Biochemical Parameters in Pre-diabetic Subjects in Bogota Colombia	nan	COMPLETED
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
The PRE-OP ENERGY Trial	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a FOXO1 binder may also engage these)

Protein	Name	Similarity
Q810W5	—	1.000	Q810W5 →
G3V7R4	—	1.000	G3V7R4 →
Q9R1E0	—	1.000	Q9R1E0 →
Q6EUW2	—	1.000	Q6EUW2 →
FOXO3	Forkhead box protein O3	1.000	landscape →
E1BPQ1	—	1.000	E1BPQ1 →
Q66JJ0	—	1.000	Q66JJ0 →
A4L7N3	—	1.000	A4L7N3 →
A3RK75	—	1.000	A3RK75 →
A3RK74	—	1.000	A3RK74 →
Q6EUW1	—	1.000	Q6EUW1 →
Q9WVH4	—	1.000	Q9WVH4 →
P78337	—	0.997	P78337 →
Q28EM1	—	0.997	Q28EM1 →
Q68F77	—	0.996	Q68F77 →
Q8R5I7	—	0.996	Q8R5I7 →
Q9CXC9	—	0.995	Q9CXC9 →
Q99NA7	—	0.995	Q99NA7 →
Q96NZ1	—	0.995	Q96NZ1 →
Q9PVZ3	—	0.995	Q9PVZ3 →
P40645	—	0.994	P40645 →
P56673	—	0.994	P56673 →
Q9DE25	—	0.994	Q9DE25 →
Q28FN6	—	0.994	Q28FN6 →
P23899	—	0.994	P23899 →
Q06453	—	0.994	Q06453 →
Q8SQ03	—	0.994	Q8SQ03 →
P35582	—	0.994	P35582 →
Q9W751	—	0.994	Q9W751 →
Q99697	—	0.994	Q99697 →