Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5543282 | 0.82 | AKR1C3 (0.46) | AKR1C3TTRHSD11B1TRPV1NOTUM | |
| SCHEMBL16398376 | 0.81 | FFAR4 (0.54) | NOTUM | |
| SCHEMBL14676114 | 0.81 | ALDH1A1 (0.46) | — | |
| SCHEMBL31622833 | 0.81 | FFAR4 (0.54) | NOTUM | |
| SCHEMBL30612347 | 0.79 | NOTUM (0.53) | NOTUM | |
| SCHEMBL27371043 | 0.79 | NOTUM (0.53) | NOTUM | |
| SCHEMBL30582933 | 0.78 | AKR1C3 (0.47) | AKR1C3TTRHSD11B1TRPV1NOTUM | |
| SCHEMBL14675703 | 0.77 | DPP4 (0.50) | HSD11B1 | |
| SCHEMBL29954991 | 0.77 | NOTUM (0.65) | AKR1C3TTRTRPV1NOTUMRBP4 | |
| SCHEMBL5799674 | 0.77 | NOTUM (0.65) | AKR1C3TTRTRPV1NOTUMRBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966199-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | Alectos Therapeutics Inc. (CA) | 2022-03-16 | — | — | EP | disclosed |