Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL507536 | 1.00 | HRH1 (0.59) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| SCHEMBL12801 | 0.98 | — | — | |
| SCHEMBL29806495 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL21486241 | 0.95 | HRH1 (0.59) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Bromide SCHEMBL27777812 | 0.93 | HRH1 (0.57) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Bromide SCHEMBL31367839 | 0.87 | HRH1 (0.58) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Bromide SCHEMBL9833906 | 0.87 | HRH1 (0.58) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Bromide SCHEMBL28641396 | 0.85 | HRH1 (0.70) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Bromide SCHEMBL10378020 | 0.85 | HRH1 (0.61) | HRH1HRH3SMN1; SMN2MAPTLIN28A | |
| Acetic Acid SCHEMBL27915207 | 0.85 | CYP1A2 (0.53) | HRH1HRH3SMN1; SMN2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160371-A | Nitrogen-phosphorus synergistic ionic flame retardant and preparation method and application thereof | 华润化学材料科技股份有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-114174263-B | Non-lysosomal glucosylceramidase inhibitors and uses thereof | 阿勒克图治疗公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-117677618-A | Novel ergoline and method for treating mood disorders | 吉尔伽美什制药公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-109863146-B | Biaryl compounds as immunomodulators | 百时美施贵宝公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-115160371-A | Nitrogen-phosphorus synergistic ionic flame retardant and preparation method and application thereof | 华润化学材料科技股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | disclosed |
| EP-3966199-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | Alectos Therapeutics Inc. (CA) | 2022-03-16 | — | — | EP | disclosed |
| CN-114174263-A | Non-lysosomal glucosylceramidase inhibitors and uses thereof | 阿勒克图治疗公司 | 2022-03-11 | — | — | CN | disclosed |