Bromide

Bromide

SCHEMBL507536

Br.BrCCc1ccccn1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.59
HRH3 Q9Y5N1 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.52
MAPT P10636 1/20 0.52
LIN28A Q9H9Z2 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
ALDH1A1 P00352 2/20 0.52
LMNA P02545 1/20 0.52
TAAR1 Q96RJ0 1/20 0.52
ALOX15 P16050 1/20 0.52
CYP1A2 P05177 4/20 0.50
CYP2D6 P10635 1/20 0.48
CYP2C19 P33261 2/20 0.46
HRH4 Q9H3N8 1/20 0.46
HSD17B10 Q99714 1/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL29448024 1.00 HRH1 (0.59) HRH1HRH3SMN1; SMN2MAPTLIN28A
SCHEMBL12801 0.98
SCHEMBL29806495 0.98
Hydrochloric Acid SCHEMBL21486241 0.95 HRH1 (0.59) HRH1HRH3SMN1; SMN2MAPTLIN28A
Bromide SCHEMBL27777812 0.93 HRH1 (0.57) HRH1HRH3SMN1; SMN2MAPTLIN28A
Bromide SCHEMBL31367839 0.87 HRH1 (0.58) HRH1HRH3SMN1; SMN2MAPTLIN28A
Bromide SCHEMBL9833906 0.87 HRH1 (0.58) HRH1HRH3SMN1; SMN2MAPTLIN28A
Bromide SCHEMBL28641396 0.85 HRH1 (0.70) HRH1HRH3SMN1; SMN2MAPTLIN28A
Bromide SCHEMBL10378020 0.85 HRH1 (0.61) HRH1HRH3SMN1; SMN2MAPTLIN28A
Acetic Acid SCHEMBL27915207 0.85 CYP1A2 (0.53) HRH1HRH3SMN1; SMN2TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115160371-A Nitrogen-phosphorus synergistic ionic flame retardant and preparation method and application thereof 华润化学材料科技股份有限公司 2022-10-11 CN claimed
US-12612414-B2 Nitrile SUMO inhibitors and uses thereof CIT THERAPEUTICS, INC. (US) 2026-04-28 US disclosed
US-12612380-B2 Non-lysosomal glucosylceramidase inhibitors and uses thereof ALECTOS THERAPEUTICS 1NC (CA) 2026-04-28 US disclosed
EP-3966199-B1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF ALECTOS THERAPEUTICS INC (CA) 2026-03-18 EP disclosed
EP-4704846-A2 NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS Gilgamesh Pharmaceuticals, Inc. (US) 2026-03-11 EP disclosed
EP-4608829-A2 NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS Gilgamesh Pharmaceuticals, Inc. (US) 2025-09-03 EP disclosed
WO-2024229454-A2 NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-11-07 WO disclosed
US-20240368151-A1 NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-11-07 US disclosed
US-20240360148-A1 NITRILE SUMO INHIBITORS AND USES THEREOF CIT THERAPEUTICS LLC 2024-10-31 US disclosed
EP-4373825-A1 NITRILE SUMO INHIBITORS AND USES THEREOF Suvalent Therapeutics, Inc. (US) 2024-05-29 EP disclosed
WO-2003043634-A1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2003-05-30 WO disclosed
EP-0993442-B1 HYDRAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP disclosed
WO-2002102782-A2 QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE NOVARTIS AG (CH) 2002-12-27 WO disclosed
EP-1261327-A2 ADENOSINE RECEPTOR MODULATORS F.HOFFMANN-LA ROCHE AG (CH) 2002-12-04 EP disclosed
US-20020147229-A1 Pharmaceuticals PFIZER INC. 2002-10-10 US disclosed
US-20010027196-A1 Adenosine receptor ligands and their use in the treatment of disease F. HOFFMANN-LA ROCHE AG (CH) 2001-10-04 US disclosed
WO-2001062233-A2 ADENOSINE RECEPTOR MODULATORS F. HOFFMANN LA ROCHE AG (CH) 2001-08-30 WO disclosed
US-6235787-B1 ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS HOFFMANN-LA ROCHE INC. 2001-05-22 US disclosed
US-4179569-A ANALGESIC INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1979-12-18 US disclosed
US-3998834-A ANALGESICS JANSSEN PHARMACEUTICA N.V. (BE) 1976-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240368151-A1 NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS HTR2C, GRIN2C, ERG HRH1 900/4885HRH3 571/4885SMN1; SMN2 1933/4885
US-20010027196-A1 Adenosine receptor ligands and their use in the treatment of disease ADORA2A, ADORA2B, ADORA1 HRH1 88/4885HRH3 131/4885SMN1; SMN2 606/4885
US-20240360148-A1 NITRILE SUMO INHIBITORS AND USES THEREOF SUMO1, SUMO3, SUMO2 HRH1 4403/4885HRH3 4546/4885SMN1; SMN2 3718/4885
US-12612414-B2 Nitrile SUMO inhibitors and uses thereof SUMO1, SUMO3, PSMB6 HRH1 2910/4885HRH3 3264/4885SMN1; SMN2 4141/4885
US-12612380-B2 Non-lysosomal glucosylceramidase inhibitors and uses thereof GBA1, GBA2, MAN2B1 HRH1 2474/4885HRH3 3053/4885SMN1; SMN2 2482/4885
US-20020147229-A1 Pharmaceuticals BDKRB1, TFPI, BDKRB2 HRH1 169/4885HRH3 415/4885SMN1; SMN2 3966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.