Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326634 | 1.00 | HSP90AB1 (0.59) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL21326598 | 0.85 | HSP90AB1 (0.56) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL29448381 | 0.85 | HSP90AB1 (0.56) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL29448360 | 0.85 | LMNA (0.61) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL21326593 | 0.85 | LMNA (0.61) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL21765314 | 0.80 | HSP90AB1 (0.54) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL19475611 | 0.78 | MEN1 (0.60) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL29448370 | 0.78 | MEN1 (0.60) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL18095881 | 0.74 | LMNA (0.54) | HSP90AB1MAPTTP53LMNAPOLB | |
| SCHEMBL4981551 | 0.74 | HSP90AB1 (0.61) | HSP90AB1MAPTTP53LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110088104-B | Tetrahydropyridopyrimidine compounds for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2022-04-12 | — | — | CN | disclosed |