Physalin A

Physalin A

SCHEMBL29449472

C=C1C(=O)O[C@@H]2C[C@@]1(C)[C@@H]1C(=O)[C@]3(O)O[C@]14[C@@]2(C)OC(=O)[C@@]4(O)CC[C@H]1[C@H]3[C@H](O)C=C2CC=CC(=O)[C@@]21C

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NFKBIA P25963 4/20 0.77
GLI1 P08151 5/20 0.50
IDH1 O75874 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Physalin A SCHEMBL15853691 1.00 NFKBIA (0.77) NFKBIAGLI1IDH1
SCHEMBL30602779 0.87 NFKBIA (1.00) NFKBIAGLI1IDH1
SCHEMBL15853690 0.87 NFKBIA (1.00) NFKBIAGLI1IDH1
Physalin O SCHEMBL15853705 0.85 GLI1 (0.59) NFKBIAGLI1IDH1
Physalin O SCHEMBL30315268 0.85 GLI1 (0.59) NFKBIAGLI1IDH1
Physalin O SCHEMBL15857092 0.85 GLI1 (0.59) NFKBIAGLI1IDH1
SCHEMBL15853695 0.78 NFKBIA (0.51) NFKBIAGLI1IDH1
SCHEMBL31301129 0.77 GLI1 (0.79) NFKBIAGLI1IDH1
SCHEMBL29449471 0.73 GLI1 (0.60) NFKBIAGLI1IDH1
SCHEMBL15853698 0.73 GLI1 (0.60) NFKBIAGLI1IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118236370-A Application of physalin A in preparation of anti-gastric cancer drugs 辽宁大学 2024-06-25 CN claimed
CN-117106006-A Preparation method of Wei Chagu Phytin A and application of Phytin A in preparation of antitumor drugs 沈阳药科大学 2023-11-24 CN claimed
CN-115452964-B UPLC characteristic spectrum construction method and quality control method of calyx seu fructus physalis 华润三九现代中药制药有限公司 2023-07-25 CN claimed
CN-113750157-B Preparation method of calyx seu fructus physalis extract, calyx seu fructus physalis extract and application thereof 中国药科大学 2022-07-29 CN claimed
CN-117106006-B Preparation method of Wei Chagu physalin A and application of Wei Chagu physalin A in preparation of antitumor drugs 沈阳药科大学 2025-08-29 CN disclosed
CN-117106006-B Preparation method of Wei Chagu physalin A and application of Wei Chagu physalin A in preparation of antitumor drugs 沈阳药科大学 2025-08-29 CN disclosed
CN-119386095-A Withanolides active component in calyx seu fructus physalis, and extraction method and application thereof 山东大学 2025-02-07 CN disclosed
CN-118754893-A Method for separating and preparing coarse extract of calyx seu fructus physalis and obtaining effective components by liquid chromatography-mass spectrometry 辽宁大学 2024-10-11 CN disclosed
CN-118754893-A Method for separating and preparing coarse extract of calyx seu fructus physalis and obtaining effective components by liquid chromatography-mass spectrometry 辽宁大学 2024-10-11 CN disclosed
CN-118236370-A Application of physalin A in preparation of anti-gastric cancer drugs 辽宁大学 2024-06-25 CN disclosed
CN-118236370-A Application of physalin A in preparation of anti-gastric cancer drugs 辽宁大学 2024-06-25 CN disclosed
CN-118236370-A Application of physalin A in preparation of anti-gastric cancer drugs 辽宁大学 2024-06-25 CN disclosed
CN-115452964-B UPLC characteristic spectrum construction method and quality control method of calyx seu fructus physalis 华润三九现代中药制药有限公司 2023-07-25 CN disclosed
CN-115452964-A UPLC characteristic spectrum construction method and quality control method of calyx seu fructus physalis 华润三九现代中药制药有限公司 2022-12-09 CN disclosed
CN-115452964-A UPLC characteristic spectrum construction method and quality control method of calyx seu fructus physalis 华润三九现代中药制药有限公司 2022-12-09 CN disclosed
CN-113750157-B Preparation method of calyx seu fructus physalis extract, calyx seu fructus physalis extract and application thereof 中国药科大学 2022-07-29 CN disclosed
CN-113750157-B Preparation method of calyx seu fructus physalis extract, calyx seu fructus physalis extract and application thereof 中国药科大学 2022-07-29 CN disclosed
CN-114634571-A Humanized CC chemokine receptor 4(CCR4) antibodies and methods of use thereof 达纳-法伯癌症研究所公司 2022-06-17 CN disclosed
CN-107849134-B Methods of mediating cytokine expression with anti-CCR 4 antibodies 达纳-法伯癌症研究所公司 2022-05-03 CN disclosed
CN-114181227-A Method for extracting physalin and method for purifying extracting solution thereof 佳木斯大学 2022-03-15 CN disclosed