Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936662 | 1.00 | NOTUM (0.43) | NOTUMTAAR1GAATLR7CYP1A2 | |
| SCHEMBL8722602 | 0.85 | NOTUM (0.50) | NOTUMCYP1A2CYP2A6LMNATSHR | |
| SCHEMBL27879107 | 0.83 | TAAR1 (0.43) | TAAR1GAACYP1A2CYP2A6LMNA | |
| SCHEMBL1541726 | 0.82 | TRPA1 (0.40) | TAAR1TRPA1TSHRHCAR1ALDH1A1 | |
| SCHEMBL802985 | 0.79 | GAA (0.41) | TAAR1GAACYP1A2CYP2A6LMNA | |
| SCHEMBL22969778 | 0.76 | NOTUM (0.43) | NOTUMCYP1A2CYP2A6LMNATSHR | |
| SCHEMBL1041749 | 0.76 | NOTUM (0.43) | NOTUMCYP1A2CYP2A6LMNATSHR | |
| SCHEMBL17972850 | 0.76 | TAAR1 (0.42) | TAAR1GAALMNABACE1MEN1 | |
| SCHEMBL21718832 | 0.76 | TAAR1 (0.38) | TAAR1GAACYP1A2CYP2A6LMNA | |
| SCHEMBL30728872 | 0.76 | TAAR1 (0.42) | TAAR1GAALMNABACE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153674-B | Iminothiadiazine dioxide derivatives as inhibitors of plasmepsin V of plasmodium | UCB生物制药有限责任公司 | 2022-03-22 | — | — | CN | disclosed |
| WO-2022053010-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-03-17 | — | — | WO | disclosed |