Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | HTT | P42858 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | MITF | O75030 | 5/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451608 | 0.79 | RAB9A (0.76) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL29451793 | 0.78 | RAB9A (0.61) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL29451353 | 0.75 | PRMT5 (0.84) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL29451775 | 0.75 | RAB9A (0.74) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL29451432 | 0.73 | RAB9A (0.58) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL5099539 | 0.73 | HTT (0.63) | RAB9AALDH1A1POLBHTTMAPT | |
| Hydrochloric Acid SCHEMBL5103337 | 0.72 | HTT (0.61) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL29451668 | 0.72 | RAB9A (0.63) | RAB9AALDH1A1POLBHTTMAPT | |
| SCHEMBL15932601 | 0.71 | NPC1 (0.69) | RAB9AALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL29451721 | 0.71 | PRMT5 (0.84) | RAB9AALDH1A1POLBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |