Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.54 |
| ▸ | MITF | O75030 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451807 | 0.87 | PRMT5 (0.67) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451487 | 0.84 | PRMT5 (0.71) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451858 | 0.84 | PRMT5 (0.71) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29452171 | 0.84 | PRMT5 (0.71) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451757 | 0.84 | PRMT5 (0.76) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29452193 | 0.79 | PRMT5 (0.66) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451392 | 0.77 | PRMT5 (0.66) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451359 | 0.77 | PRMT5 (0.66) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29452003 | 0.77 | PRMT5 (0.67) | PRMT5WDR77MITFNPC1RAB9A | |
| SCHEMBL29451763 | 0.77 | PRMT5 (0.67) | PRMT5WDR77MITFNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |