Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.66 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451359 | 1.00 | PRMT5 (0.66) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451748 | 0.88 | PRMT5 (0.52) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29452161 | 0.88 | PRMT5 (0.52) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29452151 | 0.85 | PRMT5 (0.62) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451807 | 0.85 | PRMT5 (0.67) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451728 | 0.85 | KCNJ6 (0.52) | PRMT5WDR77ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL29451921 | 0.82 | KCNJ6 (0.55) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451487 | 0.82 | PRMT5 (0.71) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451858 | 0.82 | PRMT5 (0.71) | PRMT5WDR77ALDH1A1RAB9AMAPT | |
| SCHEMBL29451755 | 0.82 | KCNJ6 (0.52) | PRMT5WDR77ALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |