Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 8/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 7/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451755 | 0.85 | KCNJ6 (0.52) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29451392 | 0.85 | PRMT5 (0.66) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29451359 | 0.85 | PRMT5 (0.66) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29452151 | 0.82 | PRMT5 (0.62) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29451779 | 0.78 | PRMT5 (0.55) | PRMT5WDR77LMNA | |
| SCHEMBL29451279 | 0.77 | PRMT5 (0.78) | PRMT5WDR77RAB9AKDM4E | |
| SCHEMBL29451961 | 0.77 | PRMT5 (0.55) | PRMT5WDR77ALDH1A1HTTLMNA | |
| SCHEMBL29451921 | 0.77 | KCNJ6 (0.55) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29451748 | 0.75 | PRMT5 (0.52) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 | |
| SCHEMBL29452161 | 0.75 | PRMT5 (0.52) | KCNJ6KCNJ3KCNJ5PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |