Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451899 | 0.85 | MEN1 (0.47) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29451976 | 0.84 | MEN1 (0.46) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29451496 | 0.82 | MEN1 (0.46) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29451395 | 0.82 | MEN1 (0.46) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29451328 | 0.81 | MEN1 (0.51) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2895158 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29451769 | 0.81 | MEN1 (0.44) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29452222 | 0.78 | MEN1 (0.48) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29452287 | 0.78 | MEN1 (0.46) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13024307 | 0.77 | SMN1; SMN2 (0.50) | ALDH1A1NPSR1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |