Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451677 | 0.85 | MAPT (0.47) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29451957 | 0.85 | MAPT (0.47) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29451536 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL29451356 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29451726 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL23909111 | 0.75 | MAPT (0.73) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29451441 | 0.75 | MAPT (0.43) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29451603 | 0.75 | MAPT (0.43) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL29452261 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL25434006 | 0.71 | POLB (0.50) | KDM4EALDH1A1HSD17B10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |