Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833481 | 0.83 | ALDH1A1 (0.51) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1819572 | 0.81 | ALDH1A1 (0.54) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25227297 | 0.79 | SCN9A (0.50) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29900515 | 0.77 | ALDH1A1 (0.60) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23092512 | 0.77 | ALDH1A1 (0.60) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1818273 | 0.77 | MEN1 (0.52) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21046986 | 0.77 | SCN9A (0.48) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22532648 | 0.77 | SCN9A (0.48) | ALDH1A1POLBKMT2ASMN1; SMN2MAPT | |
| SCHEMBL1819203 | 0.75 | MEN1 (0.57) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1817759 | 0.75 | KMT2A (0.53) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |