Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451564 | 0.82 | TSHR (0.52) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29451417 | 0.79 | KMO (0.44) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29451550 | 0.77 | KMT2A (0.51) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13172612 | 0.75 | HTR2A (0.51) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL27165381 | 0.75 | BRD4 (0.55) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10815353 | 0.74 | MEN1 (0.49) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29451973 | 0.72 | KDM4E (0.43) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL29452059 | 0.72 | KDM4E (0.43) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9877800 | 0.72 | SMN1; SMN2 (0.58) | POLBGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20553301 | 0.71 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |