Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22774462 | 1.00 | POLB (0.62) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL5212513 | 0.93 | POLB (0.68) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL22774004 | 0.91 | POLB (0.62) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL22783459 | 0.86 | ANO1 (0.73) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL29452941 | 0.86 | ANO1 (0.73) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL5210350 | 0.82 | ROCK2 (0.67) | POLBHPGDGAAMAPTTP53 | |
| SCHEMBL5214225 | 0.81 | KMT2A (0.69) | POLBHPGDMAPTTP53ROCK2 | |
| SCHEMBL1568381 | 0.81 | HDAC1 (0.72) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL11901119 | 0.81 | HPGD (0.84) | POLBHPGDGAAHDAC1HTT | |
| SCHEMBL1767439 | 0.81 | MAPT (0.69) | POLBHPGDGAAHDAC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269433-B | Modulators of TMEM16A for the treatment of respiratory diseases | TMEM16A有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-114269433-A | Modulators of TMEM16A for the treatment of respiratory diseases | TMEM16A有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2020249956-A9 | MODULATORS OF TMEM16A FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-03-03 | — | — | WO | disclosed |