SCHEMBL29454389

SCHEMBL29454389

O=C(O)C=Cc1ccccc1-c1ccccc1-c1ccccc1-c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER3 P43115 4/20 0.58
PTGER2 P43116 4/20 0.58
PTGER1 P34995 3/20 0.58
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
NFKB1 P19838 1/20 0.56
CA4 P22748 1/20 0.56
BACE1 P56817 1/20 0.51
PTGER4 P35408 3/20 0.51
HTT P42858 1/20 0.49
MAPT P10636 1/20 0.49
HDAC3 O15379 1/20 0.48
TNKS O95271 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HCAR2 Q8TDS4 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL181054 0.92 PTGER3 (0.66) PTGER3PTGER2PTGER1CA1CA2
SCHEMBL2433472 0.92 PTGER3 (0.66) PTGER3PTGER2PTGER1CA1CA2
Hydrochloric Acid SCHEMBL11527565 0.91 PTGER3 (0.64) PTGER3PTGER2PTGER1CA1CA2
SCHEMBL9297750 0.90 NFKB1 (0.67) PTGER3PTGER2PTGER1CA1CA2
SCHEMBL28399567 0.86 BACE1 (0.49) PTGER3PTGER2PTGER1CA1CA2
Biphenyl SCHEMBL29849758 0.84 PTGER3 (0.57) PTGER3PTGER2PTGER1CA1CA2
Tert-Butylamine SCHEMBL1882314 0.83 PTGER3 (0.56) PTGER3PTGER2PTGER1CA1CA2
Tert-Butylamine SCHEMBL1882312 0.83 PTGER3 (0.56) PTGER3PTGER2PTGER1CA1CA2
SCHEMBL1981788 0.82 BACE1 (0.64) PTGER3PTGER2PTGER1CA1CA2
SCHEMBL28887390 0.82 BACE1 (0.64) PTGER3PTGER2PTGER1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3579929-B1 MARSDENIA CUNDURANGO ISP INVESTMENTS LLC (US) 2022-04-13 EP claimed