Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 1.00 |
| ▸ | TTR | P02766 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | NQO2 | P16083 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945509 | 1.00 | APP (1.00) | APPTTRPTGS1ACELCK | |
| SCHEMBL698666 | 0.85 | APP (0.74) | APPLCKMAOBCYP19A1MAOA | |
| SCHEMBL698667 | 0.85 | APP (0.74) | APPLCKMAOBCYP19A1MAOA | |
| SCHEMBL1931278 | 0.85 | APP (0.73) | APPTTRPTGS1LCKNQO2 | |
| SCHEMBL698579 | 0.85 | APP (0.72) | APPPTGS1LCKMAPTMAOB | |
| SCHEMBL698580 | 0.85 | APP (0.72) | APPPTGS1LCKMAPTMAOB | |
| SCHEMBL699967 | 0.83 | APP (0.70) | APPKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL699966 | 0.83 | APP (0.70) | APPKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL29446277 | 0.83 | APP (0.70) | APPKDM4EMEN1ALDH1A1CYP1A2 | |
| (E)-3,4'-Stilbendiol SCHEMBL4167479 | 0.81 | LCK (0.72) | APPTTRPTGS1LCKNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432453-B1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2013-08-14 | — | — | EP | disclosed |
| US-7759502-B2 | Useful for inhibiting the aggregation of amyloid protein to form amyloid deposit | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-20 | — | — | US | disclosed |
| US-20080108840-A1 | Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2008-05-08 | — | — | US | disclosed |
| US-7297820-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-20 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1432453-A4 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-01-05 | — | — | US | disclosed |
| EP-1432453-A1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of The University of Pennsylvania (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-08-07 | — | — | US | disclosed |
| WO-2003018070-A1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885TTR 10/4885PTGS1 3373/4885 |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | APP 1/4885TTR 21/4885PTGS1 1973/4885 |
| US-20080108840-A1 | Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques | APP, APBA1, PSEN1 | APP 1/4885TTR 10/4885PTGS1 3373/4885 |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885TTR 10/4885PTGS1 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.