Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 9/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL16274572 | 1.00 | KCNA5 (0.40) | KCNA5NPSR1ALDH1A1KDM4EKCNN4 | |
| SCHEMBL12604118 | 0.79 | KCNA5 (0.43) | KCNA5NPSR1ALDH1A1KDM4EKCNN4 | |
| Lithium Ion SCHEMBL30327465 | 0.79 | EGLN2 (0.41) | KCNA5NPSR1ALDH1A1KDM4ECA2 | |
| SCHEMBL14020797 | 0.78 | KCNA5 (0.44) | KCNA5NPSR1ALDH1A1KDM4ECA2 | |
| SCHEMBL14020800 | 0.78 | POLB (0.44) | KCNA5NPSR1ALDH1A1KDM4EKCNN4 | |
| SCHEMBL28148498 | 0.78 | KCNA5 (0.42) | KCNA5NPSR1ALDH1A1KDM4EKCNN4 | |
| Lithium Ion SCHEMBL28371561 | 0.77 | KDM4E (0.40) | KCNA5NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL16274725 | 0.76 | EGLN2 (0.42) | KCNA5NPSR1ALDH1A1KDM4ECA2 | |
| SCHEMBL29586409 | 0.76 | EGLN2 (0.42) | KCNA5NPSR1ALDH1A1KDM4ECA2 | |
| SCHEMBL18893029 | 0.76 | KCNA5 (0.41) | KCNA5NPSR1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240147841-A1 | Organic Semiconductive Layer Comprising Phosphine Oxide Compounds | NOVALED GMBH (DE) | 2024-05-02 | — | — | US | disclosed |
| US-11711934-B2 | Metal amides for use as HIL for an organic light-emitting diode (OLED) | NOVALED GMBH (DE) | 2023-07-25 | — | — | US | disclosed |
| US-11594687-B2 | Organic electroluminescent device | NOVALED GMBH (DE) | 2023-02-28 | — | — | US | disclosed |
| US-20220407029-A1 | Metal Amides for Use as HIL for an Organic Light-Emitting Diode (OLED) | NOVALED GMBH (DE) | 2022-12-22 | — | — | US | disclosed |
| EP-4084108-A1 | METAL AMIDES FOR USE AS HIL FOR AN ORGANIC LIGHT-EMITTING DIODE (OLED) | Novaled GmbH (DE) | 2022-11-02 | — | — | EP | disclosed |
| EP-3982435-A1 | METAL AMIDES FOR USE AS HIL FOR AN ORGANIC LIGHT-EMITTING DIODE (OLED) | Novaled GmbH (DE) | 2022-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240147841-A1 | Organic Semiconductive Layer Comprising Phosphine Oxide Compounds | ALK, OR10J3, CCNT1 | KCNA5 431/4885NPSR1 1856/4885ALDH1A1 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.