Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 8/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662360 | 1.00 | TAAR1 (0.66) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL1697126 | 0.84 | MAPT (0.64) | TAAR1PRMT6KDM4ECYP3A4MAPT | |
| SCHEMBL1420648 | 0.82 | CYP1A2 (0.62) | TAAR1CYP1A2CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL3273205 | 0.81 | MAPT (0.68) | PRMT6KDM4ECYP3A4MAPTNOS1 | |
| SCHEMBL6473992 | 0.81 | TAAR1 (0.46) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL6472948 | 0.81 | TAAR1 (0.46) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL8583518 | 0.79 | CYP1A2 (0.65) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL2909601 | 0.79 | TAAR1 (1.00) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL29672948 | 0.79 | CYP1A2 (0.65) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 | |
| SCHEMBL23732924 | 0.79 | TAAR1 (0.51) | TAAR1CYP1A2CYP2D6CYP2C19PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178563-A1 | TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS MTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE | Technion Research & Development Foundation Ltd. (IL) | 2023-05-17 | — | — | EP | disclosed |
| CN-112409224-B | Synthetic method of sulfonamide compound | 四川大学 | 2022-02-15 | — | — | CN | disclosed |