Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.62 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617866 | 0.84 | NPC1 (0.58) | BRD4CREBBPAHRPDK2NPC1 | |
| SCHEMBL25975997 | 0.77 | MMP12 (0.45) | BRD4CREBBPAHRMAPTEPHX2 | |
| SCHEMBL677636 | 0.77 | BRD4 (1.00) | BRD4CREBBPAHRPDK2NPC1 | |
| SCHEMBL2061242 | 0.76 | CA9 (0.58) | BRD4CREBBPAHRMAPTALDH1A1 | |
| SCHEMBL21257784 | 0.76 | PDE3B (0.46) | BRD4CREBBPMAPTALDH1A1HTT | |
| SCHEMBL25249364 | 0.76 | CMA1 (0.60) | BRD4CREBBPAHRMAPTCASP2 | |
| SCHEMBL5107807 | 0.76 | AHR (0.60) | BRD4AHRMAOAMAOBKMT2A | |
| SCHEMBL26228613 | 0.75 | PARP1 (0.50) | BRD4CREBBPAHREPHX2MAOA | |
| SCHEMBL31332406 | 0.75 | EPHX2 (0.57) | BRD4CREBBPAHRPDK2NPC1 | |
| SCHEMBL17506418 | 0.74 | AHR (0.50) | BRD4CREBBPAHRPDK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019154261-A1 | PYRIDINE DERIVATIVE RELATED TO KMD5 PATHWAY | 南京明德新药研发股份有限公司 | 2019-08-15 | — | — | WO | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| EP-1116716-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | Eisai Co., Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-0579263-B1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | EISAI CO LTD (JP) | 1998-09-16 | — | — | EP | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0579263-A1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1994-01-19 | — | — | EP | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| US-4886797-A | CENTRAL NERVOUS SYSTEM DISORDERS | A/S FERROSAN (DK) | 1989-12-12 | — | — | US | disclosed |
| US-4880799-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANTICONVULSANTS | A/S FERROSAN (DK) | 1989-11-14 | — | — | US | disclosed |
| US-4870073-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANTHELMINTICS, PARASITICIDES, INSECTICIDES | A/S FERROSAN (DK) | 1989-09-26 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0220845-A1 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-05-06 | — | — | EP | disclosed |