Fatostatin

Fatostatin

SCHEMBL29458338

CCCc1cc(-c2nc(-c3ccc(C)cc3)cs2)ccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SREBF2 Q12772 17/20 1.00
MAPT P10636 3/20 0.97
ATM Q13315 3/20 0.97
L3MBTL1 Q9Y468 2/20 0.97
ALDH1A1 P00352 1/20 0.97
SREBF1 P36956 2/20 0.81
KDM4E B2RXH2 2/20 0.77
LMNA P02545 2/20 0.77
RECQL P46063 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fatostatin SCHEMBL2742732 1.00 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
Fatostatin SCHEMBL25327929 0.99 MAPT (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL19758233 0.95 SREBF2 (0.90) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4279559 0.89 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4293604 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4290927 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4285116 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4286504 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4292296 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1
SCHEMBL4283881 0.88 SREBF2 (1.00) SREBF2MAPTATML3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122031716-A Carbon microsphere delivery carrier with controllable size in large range and preparation method and application thereof 广州墨羲科技有限公司 2026-05-15 CN claimed
US-20250297321-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM INST NAT SANTE RECH MED (FR) 2025-09-25 US claimed
CN-120114568-A Application of Ras related protein Rab-3B in treatment of neuroblastoma 大连市妇女儿童医疗中心(集团) 2025-06-10 CN claimed
US-20250177367-A1 COMBINATION THERAPIES FOR MODULATION OF LIPID PRODUCTION OHIO STATE INNOVATION FOUNDATION 2025-06-05 US claimed
CN-119677539-A Combination therapy for modulating lipid production 俄亥俄州创新基金会 2025-03-21 CN claimed
US-20250049773-A1 INHIBITION OF STEROL RESPONSE ELEMENT BINDING PROTEINS AS ATARGET FOR SELECTIVE ELIMINATION OF SENESCENT CELLS TRUSTEES OF TUFTS COLLEGE 2025-02-13 US claimed
CN-119386185-A G6PD inhibitor and Fatostatin combined application for treating glioma 潍坊市人民医院(潍坊市公共卫生临床中心) 2025-02-07 CN claimed
EP-4489865-A2 COMBINATION THERAPIES FOR MODULATION OF LIPID PRODUCTION Ohio State Innovation Foundation (US) 2025-01-15 EP claimed
EP-4469602-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM Université Paris Cité (FR) 2024-12-04 EP claimed
WO-2023172669-A9 COMBINATION THERAPIES FOR MODULATION OF LIPID PRODUCTION OHIO STATE INNOVATION FOUNDATION (US) 2024-08-02 WO claimed
US-12036218-B2 Modulators of airway basal cells for the treatment or prevention of lung diseases Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. (DE) 2024-07-16 US claimed
CN-117414428-A Combined use of G6PD inhibitors and inhibitors of novel molecular sites 潍坊市人民医院(潍坊市公共卫生临床中心) 2024-01-19 CN claimed
WO-2023172669-A2 COMBINATION THERAPIES FOR MODULATION OF LIPID PRODUCTION OHIO STATE INNOVATION FOUNDATION (US) 2023-09-14 WO claimed
WO-2023144357-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM UNIVERSITE PARIS CITE (FR) 2023-08-03 WO claimed
EP-4219764-A1 METHOD FOR DETECTING METABOLIC REPROGRAMING OF CANCER TOWARDS FATTY ACIDS METABOLISM Université Paris Cité (FR) 2023-08-02 EP claimed
WO-2023097280-A1 INHIBITION OF STEROL RESPONSE ELEMENT BINDING PROTEINS AS A TARGET FOR SELECTIVE ELIMINATION OF SENESCENT CELLS TRUSTEES OF TUFTS COLLEGE (US) 2023-06-01 WO claimed
CN-116077493-A Application of Fatostatin as medicine for treating atopic dermatitis, ointment and preparation method thereof 中国人民解放军空军军医大学 2023-05-09 CN claimed
CN-115299453-B Application of Fatostatin as synergist of insect growth regulator in preparing insecticide 华南农业大学 2023-04-18 CN claimed
CN-115299453-A Application of Fatostatin as synergist of insect growth regulator in preparing insecticide 华南农业大学 2022-11-08 CN claimed
WO-2022120197-A1 COMBINATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEIN INHIBITORS FOR USES IN CANCER THERAPIES EMORY UNIVERSITY (US) 2022-06-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250049773-A1 INHIBITION OF STEROL RESPONSE ELEMENT BINDING PROTEINS AS ATARGET FOR SELECTIVE ELIMINATION OF SENESCENT CELLS SREBF1, SREBF2, OSBP SREBF2 2/4885MAPT 3724/4885ATM 345/4885
US-20250177367-A1 COMBINATION THERAPIES FOR MODULATION OF LIPID PRODUCTION ACACB, SREBF2, FASN SREBF2 2/4885MAPT 1292/4885ATM 1016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.