Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.59 |
| ▸ | CDK2 | P24941 | 10/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.59 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCND3 | P30281 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.57 |
| ▸ | PIM1 | P11309 | 4/20 | 0.57 |
| ▸ | MTOR | P42345 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CCNK | O75909 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458629 | 0.88 | CCNT1 (0.56) | CDK4CCND3BRD4EGFR | |
| SCHEMBL29458711 | 0.87 | TNK2 (0.56) | CDK2CDK4CCND3AURKASLC2A1 | |
| SCHEMBL29458578 | 0.87 | TNK2 (0.56) | CDK4CCND3SLC2A1BRD4EGFR | |
| SCHEMBL29458704 | 0.84 | TNK2 (0.61) | EGFR | |
| SCHEMBL29458565 | 0.76 | PTK2 (0.49) | EGFR | |
| SCHEMBL10098751 | 0.74 | NUAK1 (0.62) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL16065776 | 0.74 | TNK2 (0.79) | — | |
| SCHEMBL25068526 | 0.74 | CCNA2 (1.00) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL29458512 | 0.74 | MAPK7 (0.56) | CDK4EGFR | |
| SCHEMBL4154077 | 0.73 | CCNA2 (0.53) | CCNA2CDK2CCNA1CDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836427-B | Pyrimidopyrimidinone compounds and application thereof | 暨南大学 | 2022-04-15 | — | — | CN | disclosed |