Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 9/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458711 | 0.88 | TNK2 (0.56) | JAK2TBK1EGFRCSF1RFLT3 | |
| SCHEMBL29458578 | 0.78 | TNK2 (0.56) | JAK2EGFRFLT3TNK2JAK3 | |
| SCHEMBL29458629 | 0.78 | CCNT1 (0.56) | JAK2EGFRFLT3JAK3JAK1 | |
| SCHEMBL29458704 | 0.76 | TNK2 (0.61) | EGFRFLT3PDGFRBPDGFRAFGFR3 | |
| SCHEMBL29458796 | 0.76 | CCNA2 (0.59) | EGFR | |
| SCHEMBL17631196 | 0.75 | TBK1 (0.53) | PTK2JAK2TBK1FGFR3 | |
| SCHEMBL17630254 | 0.74 | TBK1 (0.55) | PTK2JAK2TBK1EGFRCSF1R | |
| SCHEMBL29458512 | 0.69 | MAPK7 (0.56) | EGFRTNK2TTK | |
| SCHEMBL21204468 | 0.68 | TBK1 (0.82) | JAK2TBK1 | |
| SCHEMBL20260877 | 0.67 | TBK1 (0.43) | PTK2JAK2TBK1EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836427-B | Pyrimidopyrimidinone compounds and application thereof | 暨南大学 | 2022-04-15 | — | — | CN | claimed |
| CN-109836427-B | Pyrimidopyrimidinone compounds and application thereof | 暨南大学 | 2022-04-15 | — | — | CN | disclosed |