Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116847 | 0.78 | ABL1 (0.45) | — | |
| SCHEMBL5775602 | 0.77 | NPC1 (0.37) | NOTUMGAALMNAPKMMEN1 | |
| SCHEMBL31143361 | 0.77 | MAPT (0.50) | CYP3A4QPCTQPCTL | |
| SCHEMBL6008269 | 0.77 | MAPT (0.50) | CYP3A4QPCTQPCTL | |
| SCHEMBL2461139 | 0.76 | ALK (0.44) | MEN1KMT2AKEAP1QPCTQPCTL | |
| SCHEMBL23123086 | 0.73 | QPCT (0.51) | QPCTQPCTL | |
| SCHEMBL2462703 | 0.73 | NOTUM (0.43) | NOTUMCYP2D6QPCTQPCTL | |
| SCHEMBL2457410 | 0.73 | PSMD11 (0.42) | QPCTQPCTL | |
| SCHEMBL16005249 | 0.72 | DYRK1A (0.53) | CYP11B1CYP11B2NOTUMGAALMNA | |
| SCHEMBL991450 | 0.72 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP3A4CYP2D6QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225441-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | Endogena Therapeutics, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076417-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | ENDOGENA THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |