SCHEMBL2946175

SCHEMBL2946175

CCNc1ncc(Br)cc1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
MAPT P10636 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPC1 O15118 2/20 0.37
PGK1 P00558 2/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
PKM P14618 1/20 0.36
GRM5 P41594 1/20 0.35
IDO1 P14902 1/20 0.34
CHRNA7 P36544 1/20 0.34
GAA P10253 1/20 0.33
ALOX12 P18054 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19189539 0.86 HTT (0.45) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL25083596 0.81 JAK2 (0.36) PGK1CHRNA7JAK2JAK3KDM4E
SCHEMBL19260116 0.79 ALDH1A1 (0.40) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL3848724 0.79 MAPT (0.45) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL2068017 0.79 ALDH1A1 (0.39) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL31690174 0.78 ALDH1A1 (0.34) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL15649492 0.78 KMT2A (0.39) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
SCHEMBL21360995 0.78 MAPK1 (0.38) CYP2C9PGK1CHRNA7JAK2JAK3
SCHEMBL28715816 0.78 MAPT (0.38) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL28665193 0.77 ALDH1A1 (0.38) ALDH1A1MAPTCYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396301-A2 SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS Jerini AG (DE) 2011-12-21 EP disclosed
WO-2010091876-A2 SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS JERINI AG (DE) 2010-08-19 WO disclosed