Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24660167 | 1.00 | CTSS (0.48) | CTSSCTSKCTSBTDP1PPARD | |
| SCHEMBL24660606 | 0.88 | TDP1 (0.50) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL29463534 | 0.88 | TDP1 (0.50) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL22637673 | 0.86 | TDP1 (0.54) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL24660585 | 0.85 | S1PR3 (0.51) | TDP1PPARDPPARAKCNT1ACACB | |
| SCHEMBL22649167 | 0.83 | KCNT1 (0.57) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL22649477 | 0.83 | PPARD (0.49) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL22649521 | 0.83 | KCNT1 (0.57) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL29463464 | 0.83 | KCNT1 (0.57) | TDP1PPARDPPARATP53SMN1; SMN2 | |
| SCHEMBL29463495 | 0.83 | PPARD (0.49) | TDP1PPARDPPARATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259193-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2022-08-18 | — | — | US | disclosed |
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259193-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | CTSS 3102/4885CTSK 2145/4885CTSB 2898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.