Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 16/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201791 | 0.78 | PDE4D (0.63) | HCAR2PDE4DMEN1KMT2APLAT | |
| SCHEMBL28359190 | 0.74 | HCAR2 (0.50) | HCAR2CCNA2CDK2CCNA1SLC6A4 | |
| SCHEMBL27758273 | 0.73 | PDE4D (0.48) | PDE4DCYP2C19PLAT | |
| SCHEMBL27758237 | 0.73 | HCAR2 (0.42) | HCAR2CYP2C19 | |
| SCHEMBL1663754 | 0.71 | PDE4D (0.59) | HCAR2PDE4DMEN1CYP2C19KMT2A | |
| SCHEMBL16231396 | 0.71 | DYRK1A (0.44) | HCAR2 | |
| SCHEMBL3544924 | 0.71 | PDE10A (0.42) | HCAR2PDE4DMEN1KMT2A | |
| SCHEMBL21834224 | 0.70 | HCAR2 (0.40) | HCAR2PDE4DCCNA2CDK2CCNA1 | |
| SCHEMBL4443157 | 0.68 | SIRT1 (0.50) | HCAR2CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL16979319 | 0.68 | HCAR2 (0.52) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |