Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658834 | 1.00 | CYP19A1 (0.46) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL10066877 | 0.86 | CYP3A4 (0.54) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL28614447 | 0.84 | CYP3A4 (0.52) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL16923125 | 0.81 | CYP3A4 (0.48) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL31138265 | 0.78 | CYP3A4 (0.46) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL2643486 | 0.78 | CYP3A4 (0.51) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL13805938 | 0.78 | CYP3A4 (0.51) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL12487845 | 0.78 | LMNA (0.47) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL16265230 | 0.77 | CYP3A4 (0.44) | CYP19A1CYP11B1CYP11B2CYP3A4CYP1A2 | |
| SCHEMBL30270572 | 0.74 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2D6TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114258393-B | Heterocyclic compounds having dual inhibitory activity of phosphatidylinositol 3-kinase delta and gamma and medical uses thereof | 中国医药研究开发中心有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-114258393-A | Heterocyclic compound with dual phosphatidylinositol 3-kinase delta and gamma inhibitor activity and medical application thereof | 中国医药研究开发中心有限公司 | 2022-03-29 | — | — | CN | disclosed |