Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925146 | 1.00 | HSD11B1 (0.39) | HSD11B1SLC40A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL19927703 | 0.90 | HSD11B1 (0.37) | HSD11B1SLC40A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29464412 | 0.90 | HSD11B1 (0.37) | HSD11B1SLC40A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL24360899 | 0.89 | HSD11B1 (0.39) | HSD11B1SLC40A1KDM4EALDH1A1HPGD | |
| SCHEMBL19925060 | 0.87 | HSD11B1 (0.36) | HSD11B1L3MBTL1ALDH1A1SLC22A12MEN1 | |
| SCHEMBL29464522 | 0.87 | HSD11B1 (0.36) | HSD11B1L3MBTL1ALDH1A1SLC22A12MEN1 | |
| SCHEMBL19925021 | 0.86 | HSD11B1 (0.34) | HSD11B1L3MBTL1KDM4EALDH1A1SLC22A12 | |
| SCHEMBL29464338 | 0.86 | HSD11B1 (0.34) | HSD11B1L3MBTL1KDM4EALDH1A1SLC22A12 | |
| SCHEMBL19968767 | 0.85 | HSD11B1 (0.39) | HSD11B1SLC40A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29464483 | 0.85 | HSD11B1 (0.39) | HSD11B1SLC40A1L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |