Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | WNT3 | P56703 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | KAT7 | O95251 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 2/20 | 0.33 |
| ▸ | SKP1 | P63208 | 2/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464438 | 1.00 | MCL1 (0.39) | MCL1SFRP1HDAC6HDAC8SMARCA2 | |
| SCHEMBL19925020 | 1.00 | MCL1 (0.39) | MCL1SFRP1HDAC6HDAC8SMARCA2 | |
| SCHEMBL19925770 | 1.00 | MCL1 (0.39) | MCL1SFRP1HDAC6HDAC8SMARCA2 | |
| SCHEMBL19925175 | 0.88 | CKS1B (0.41) | SFRP1SMARCA2SMARCA4PBRM1TGFBR1 | |
| SCHEMBL29464343 | 0.88 | CKS1B (0.41) | SFRP1SMARCA2SMARCA4PBRM1TGFBR1 | |
| SCHEMBL29464410 | 0.87 | MCL1 (0.38) | MCL1SFRP1WNT3 | |
| SCHEMBL19925691 | 0.87 | MCL1 (0.38) | MCL1SFRP1WNT3 | |
| SCHEMBL19927718 | 0.87 | MCL1 (0.38) | MCL1SFRP1WNT3 | |
| SCHEMBL29464470 | 0.87 | MCL1 (0.38) | MCL1SFRP1WNT3 | |
| SCHEMBL23770700 | 0.85 | HDAC6 (0.36) | MCL1SFRP1HDAC6HDAC8SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |