Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.33 |
| ▸ | CKS1B | P61024 | 2/20 | 0.33 |
| ▸ | SKP1 | P63208 | 2/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770697 | 0.87 | CKS1B (0.41) | SMARCA2SMARCA4PBRM1CKS1BSKP1 | |
| SCHEMBL23770692 | 0.87 | EIF2AK4 (0.38) | MCL1SFRP1CKS1BSKP1SKP2 | |
| SCHEMBL29464438 | 0.85 | MCL1 (0.39) | HDAC6HDAC8MCL1SMARCA2SMARCA4 | |
| SCHEMBL19925770 | 0.85 | MCL1 (0.39) | HDAC6HDAC8MCL1SMARCA2SMARCA4 | |
| SCHEMBL29464355 | 0.85 | MCL1 (0.39) | HDAC6HDAC8MCL1SMARCA2SMARCA4 | |
| SCHEMBL19925020 | 0.85 | MCL1 (0.39) | HDAC6HDAC8MCL1SMARCA2SMARCA4 | |
| SCHEMBL23770846 | 0.83 | HTR2C (0.35) | — | |
| SCHEMBL23770806 | 0.81 | RBP4 (0.36) | SYKRORC | |
| SCHEMBL23770842 | 0.81 | RBP4 (0.32) | — | |
| SCHEMBL23770612 | 0.79 | GPR119 (0.41) | CKS1BSKP1SKP2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |