Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968844 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL29464919 | 0.99 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL19925388 | 0.99 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL19968838 | 0.91 | SCN9A (0.36) | SMN1; SMN2LMNAKDM4ESCN9ATACR1 | |
| SCHEMBL29464434 | 0.91 | SCN9A (0.36) | SMN1; SMN2LMNAKDM4ESCN9ATACR1 | |
| SCHEMBL19925160 | 0.90 | SCN9A (0.36) | SMN1; SMN2LMNAKDM4ESCN9ATACR1 | |
| SCHEMBL19968866 | 0.87 | SCN9A (0.39) | ALDH1A1KDM4ESCN9ATACR1TP53 | |
| SCHEMBL19968837 | 0.87 | SFRP1 (0.36) | MAPTALDH1A1LMNAPOLBKDM4E | |
| SCHEMBL29464370 | 0.87 | CYP1A2 (0.42) | ALDH1A1KDM4ESCN9ATACR1 | |
| SCHEMBL19968842 | 0.87 | CYP1A2 (0.42) | ALDH1A1KDM4ESCN9ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |