Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 14/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 14/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.35 |
| ▸ | SDHB | P21912 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19927705 | 1.00 | SCN1A (0.38) | SCN1ASCN8AHSD11B1SCN5ASDHB | |
| SCHEMBL24360899 | 0.89 | HSD11B1 (0.39) | SCN1ASCN8AHSD11B1SCN5ASLC40A1 | |
| SCHEMBL19968790 | 0.89 | SCN1A (0.39) | SCN1ASCN8AHSD11B1SCN5A | |
| SCHEMBL29464970 | 0.89 | SCN1A (0.39) | SCN1ASCN8AHSD11B1SCN5A | |
| SCHEMBL19927703 | 0.88 | HSD11B1 (0.37) | HSD11B1SDHBSLC40A1KDM4EALDH1A1 | |
| SCHEMBL22323258 | 0.88 | SCN1A (0.38) | SCN1ASCN8AHSD11B1SCN5ASLC40A1 | |
| SCHEMBL29464412 | 0.88 | HSD11B1 (0.37) | HSD11B1SDHBSLC40A1KDM4EALDH1A1 | |
| SCHEMBL19925692 | 0.88 | SCN1A (0.38) | SCN1ASCN8AHSD11B1SCN5A | |
| SCHEMBL29464850 | 0.88 | SCN1A (0.38) | SCN1ASCN8AHSD11B1SCN5A | |
| SCHEMBL22323213 | 0.87 | SCN1A (0.41) | SCN1ASCN8AHSD11B1SCN5ASLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |