Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 3/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.38 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22772840 | 1.00 | SGK1 (0.50) | SGK1GRIN2BGRIN1KCNH2MAPK1 | |
| SCHEMBL22772817 | 0.86 | SGK1 (0.52) | SGK1GRIN2BGRIN1MAPK1 | |
| SCHEMBL29465747 | 0.86 | SGK1 (0.52) | SGK1GRIN2BGRIN1MAPK1 | |
| SCHEMBL22771356 | 0.78 | GRIN2B (0.51) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL22772822 | 0.77 | SGK1 (0.50) | SGK1GRIN2BGRIN1KCNH2MAPK1 | |
| SCHEMBL30014996 | 0.75 | SGK1 (0.47) | SGK1GRIN2BMAPK1 | |
| SCHEMBL30014865 | 0.75 | SGK1 (0.49) | SGK1GRIN2BMAPK1 | |
| SCHEMBL22772832 | 0.73 | GRIN2B (0.52) | SGK1GRIN2BGRIN1KCNH2 | |
| SCHEMBL28685790 | 0.72 | GRIN2B (0.44) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL19398615 | 0.71 | GRIN2B (0.52) | GRIN2BGRIN1KCNH2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983413-A1 | SUBSTITUTED PYRAZOLO-PYRAZINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |