Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 3/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22772817 | 1.00 | SGK1 (0.52) | SGK1GRIN2BNOTUMGRIN1KIF20B | |
| SCHEMBL22772840 | 0.86 | SGK1 (0.50) | SGK1GRIN2BGRIN1MAPK1 | |
| SCHEMBL29465746 | 0.86 | SGK1 (0.50) | SGK1GRIN2BGRIN1MAPK1 | |
| SCHEMBL29901465 | 0.79 | GRIN2B (0.53) | GRIN2BNOTUMGRIN1 | |
| SCHEMBL30015184 | 0.74 | GRIN2B (0.48) | SGK1GRIN2BMAPK1MAPT | |
| SCHEMBL22772850 | 0.74 | GRIN2B (0.50) | SGK1GRIN2BGRIN1 | |
| SCHEMBL28689684 | 0.72 | GRIN2B (0.45) | GRIN2BNOTUMGRIN1KIF20BCTSS | |
| SCHEMBL22787220 | 0.69 | GRIN2B (0.81) | GRIN2B | |
| SCHEMBL30014996 | 0.69 | SGK1 (0.47) | SGK1GRIN2BMAPK1 | |
| SCHEMBL30014845 | 0.69 | BCHE (0.61) | SGK1GRIN2BMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983413-A1 | SUBSTITUTED PYRAZOLO-PYRAZINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |