SCHEMBL29468137

SCHEMBL29468137

Cc1nc2cnc(Cl)c(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(C(=O)OC(C)(C)C)csc12

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29560096 0.92 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866523 0.92 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560206 0.92 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560441 0.91 EIF4EBP1 (0.75) EIF4EBP1
SCHEMBL29468136 0.91 EIF4EBP1 (0.73) EIF4EBP1
SCHEMBL29468129 0.88 EIF4EBP1 (0.69) EIF4EBP1
SCHEMBL22866774 0.87 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866702 0.87 EIF4EBP1 (0.75) EIF4EBP1
SCHEMBL22866564 0.87 EIF4EBP1 (0.71) EIF4EBP1
SCHEMBL29661940 0.87 EIF4EBP1 (0.75) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230108594-A1 EIF4E-INHIBITING COMPOUNDS AND METHODS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-04-06 — — US disclosed
EP-3994139-A1 EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS Effector Therapeutics Inc. (US) 2022-05-11 — — EP disclosed
US-11286268-B1 EIF4E-inhibiting compounds and methods EFFECTOR THERAPEUTICS, INC. (US) 2022-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11286268-B1 EIF4E-inhibiting compounds and methods EIF4E, EIF4EBP1, EIF4A1 EIF4EBP1 2/4885
US-20230108594-A1 EIF4E-INHIBITING COMPOUNDS AND METHODS EIF4E, EIF4EBP1, EIF4A1 EIF4EBP1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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