Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198768 | 1.00 | POLB (0.44) | POLBMAPTKDM4EALDH1A1RECQL | |
| SCHEMBL14822549 | 0.80 | ENPP2 (0.43) | MAPTALDH1A1RECQLHPGDENPP2 | |
| SCHEMBL3783705 | 0.79 | MAPT (0.35) | POLBMAPTKDM4EALDH1A1RECQL | |
| SCHEMBL6524293 | 0.78 | ENPP2 (0.41) | MAPTALDH1A1RECQLENPP2SMN1; SMN2 | |
| SCHEMBL28627138 | 0.78 | ENPP2 (0.41) | MAPTALDH1A1RECQLENPP2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11102831 | 0.78 | ENPP2 (0.41) | MAPTALDH1A1RECQLHPGDENPP2 | |
| SCHEMBL22056727 | 0.78 | ENPP2 (0.41) | MAPTALDH1A1RECQLHPGDENPP2 | |
| SCHEMBL3790482 | 0.78 | KDM4E (0.34) | POLBMAPTKDM4EALDH1A1RECQL | |
| SCHEMBL20296892 | 0.78 | ENPP2 (0.38) | MAPTALDH1A1RECQLHSD17B10ENPP2 | |
| SCHEMBL14253215 | 0.76 | ENPP2 (0.40) | MAPTALDH1A1RECQLENPP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122037235-A | Hydrogel buffer pad and preparation method and application thereof | 浙江省农业科学院 | 2026-05-15 | — | — | CN | claimed |
| CN-122037235-A | Hydrogel buffer pad and preparation method and application thereof | 浙江省农业科学院 | 2026-05-15 | — | — | CN | disclosed |
| WO-2025024543-A1 | TRICYCLIC UBE2K MODULATORS AND METHODS FOR THEIR USE | BPGBIO, INC. (US) | 2025-01-30 | — | — | WO | disclosed |
| US-12083121-B2 | Substituted piperazines as KRAS G12C inhibitors | AMGEN INC. (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220175782-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. | 2022-06-09 | — | — | US | disclosed |
| US-11285156-B2 | Substituted piperazines as KRAS G12C inhibitors | AMGEN INC. (US) | 2022-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11285156-B2 | Substituted piperazines as KRAS G12C inhibitors | KRAS, NRAS, HRAS | POLB 596/4885MAPT 4138/4885KDM4E 3093/4885 |
| US-12083121-B2 | Substituted piperazines as KRAS G12C inhibitors | KRAS, NRAS, HRAS | POLB 596/4885MAPT 4138/4885KDM4E 3093/4885 |
| US-20220175782-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | POLB 632/4885MAPT 3991/4885KDM4E 4110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.