Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333992 | 1.00 | ACACB (0.39) | ACACBSCN9ASLC6A9ALDH1A1SMN1; SMN2 | |
| SCHEMBL29469664 | 0.91 | ALDH1A1 (0.44) | ACACBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29469631 | 0.91 | ACACB (0.40) | ACACBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24333455 | 0.91 | ACACB (0.40) | ACACBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24334019 | 0.89 | KCNH2 (0.39) | SCN9ASLC6A9ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL24333736 | 0.89 | SCN9A (0.38) | SCN9ASLC6A9ALDH1A1SCN5ASCN7A | |
| SCHEMBL29469627 | 0.89 | KCNH2 (0.39) | SCN9ASLC6A9ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29469681 | 0.89 | SCN9A (0.38) | SCN9ASLC6A9ALDH1A1SCN5ASCN7A | |
| SCHEMBL24333447 | 0.88 | ALDH1A1 (0.38) | SLC6A9ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29469624 | 0.88 | ALDH1A1 (0.38) | SLC6A9ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |