Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.62 |
| ▸ | CA2 | P00918 | 12/20 | 0.62 |
| ▸ | CA9 | Q16790 | 11/20 | 0.62 |
| ▸ | CA7 | P43166 | 8/20 | 0.62 |
| ▸ | CA12 | O43570 | 7/20 | 0.62 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610159 | 1.00 | CA1 (0.62) | CA1CA2CA9CA7CA12 | |
| SCHEMBL9058916 | 0.85 | TP53 (0.53) | CA1CA2CA9CA7CA12 | |
| SCHEMBL3936854 | 0.85 | CA1 (0.68) | CA1CA2CA9CA7CA12 | |
| SCHEMBL14773591 | 0.84 | TP53 (0.52) | CA1CA2CA9CA7CA12 | |
| SCHEMBL13592998 | 0.84 | TP53 (0.52) | CA1CA2CA9CA7CA12 | |
| SCHEMBL3492741 | 0.82 | KAT6A (0.51) | CA1CA2CA9CA7CA12 | |
| SCHEMBL5610156 | 0.82 | KAT6A (0.51) | CA1CA2CA9CA7CA12 | |
| SCHEMBL3283827 | 0.82 | TP53 (0.50) | CA1CA2CA9CA7CA12 | |
| SCHEMBL24686632 | 0.81 | KAT6A (0.50) | CA1CA2CA9CA7CA12 | |
| SCHEMBL28236411 | 0.81 | TP53 (0.49) | CA1CA2CA9CA7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4058439-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | Genzyme Corporation (US) | 2022-09-21 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |