Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.49 |
| ▸ | PRKACG | P22612 | 2/20 | 0.49 |
| ▸ | PRKACB | P22694 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000333 | 1.00 | ROCK2 (0.50) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| SCHEMBL14256991 | 0.85 | ROCK2 (0.51) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| SCHEMBL12571556 | 0.83 | ROCK2 (0.50) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| SCHEMBL2001999 | 0.81 | MAPT (0.41) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| SCHEMBL2006560 | 0.80 | ROCK2 (0.34) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| SCHEMBL31537 | 0.80 | ROCK2 (0.47) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| Iodide SCHEMBL28700199 | 0.79 | ROCK2 (0.46) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| Bromide SCHEMBL28709695 | 0.79 | ROCK2 (0.46) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| Hydrochloric Acid SCHEMBL7823569 | 0.79 | ROCK2 (0.33) | ROCK2ROCK1PRKCDPRKD3PRKCZ | |
| Hydrochloric Acid SCHEMBL999448 | 0.79 | ROCK2 (0.47) | ROCK2ROCK1PRKCDPRKD3PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |