Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18912560 | 0.75 | KCNH2 (0.66) | AXLKCNH2JAK2CDK9JAK3 | |
| SCHEMBL12082405 | 0.75 | ALDH1A1 (0.53) | NPC1MAPTRAB9AKDM4ETAAR1 | |
| SCHEMBL13485401 | 0.74 | JAK3 (0.68) | AXLBRD4JAK2FLT3CCND3 | |
| SCHEMBL13485386 | 0.74 | JAK3 (0.68) | AXLBRD4JAK2FLT3CCND3 | |
| SCHEMBL28717256 | 0.74 | KDM4E (0.62) | AXLNPC1MAPTRAB9AKDM4E | |
| SCHEMBL12965679 | 0.73 | AXL (0.52) | AXLKDM4EBRD4JAK2FLT3 | |
| SCHEMBL29575740 | 0.72 | AXL (0.62) | AXLBRD4JAK2FLT3CDK6 | |
| SCHEMBL5686213 | 0.72 | FLT3 (0.58) | AXLKDM4EBRD4JAK2FLT3 | |
| SCHEMBL3211154 | 0.71 | AXL (0.65) | AXLBRD4JAK2CCND3JAK3 | |
| SCHEMBL8352983 | 0.71 | KDM4E (0.58) | AXLNPC1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391676-B2 | BRD4-JAK2 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2025-08-19 | — | — | US | disclosed |
| US-20220119370-A1 | BRD4-JAK2 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12391676-B2 | BRD4-JAK2 inhibitors | BRD4, BICRA, JAK2 | AXL 2245/4885NPC1 4192/4885MAPT 4454/4885 |
| US-20220119370-A1 | BRD4-JAK2 INHIBITORS | BRD4, BICRA, JAK2 | AXL 2245/4885NPC1 4192/4885MAPT 4454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.