Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26548496 | 1.00 | GSK3B (0.38) | GSK3BDYRK1AWNT1LRRK2RET | |
| SCHEMBL29471161 | 0.90 | BRD4 (0.37) | GSK3BDYRK1AWNT1LRRK2BRD4 | |
| SCHEMBL24316676 | 0.90 | BRD4 (0.37) | GSK3BDYRK1AWNT1LRRK2BRD4 | |
| SCHEMBL29471148 | 0.87 | CREBBP (0.37) | GSK3BDYRK1AWNT1BRD4CREBBP | |
| SCHEMBL24316675 | 0.87 | CREBBP (0.37) | GSK3BDYRK1AWNT1BRD4CREBBP | |
| SCHEMBL24316581 | 0.86 | RET (0.36) | RETCREBBPPRMT5WDR77USP30 | |
| SCHEMBL29471251 | 0.86 | RET (0.36) | RETCREBBPPRMT5WDR77USP30 | |
| SCHEMBL29471289 | 0.83 | RET (0.36) | RETCREBBPPRMT5WDR77USP30 | |
| SCHEMBL24316610 | 0.80 | FGFR1 (0.40) | LRRK2BRD4CREBBPMET | |
| SCHEMBL29471262 | 0.80 | MAPT (0.37) | BRD4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210683-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | Aurigene Oncology Limited (IN) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022053967-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-03-17 | — | — | WO | disclosed |