Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 13/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 13/20 | 0.35 |
| ▸ | WNT1 | P04628 | 11/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316675 | 1.00 | CREBBP (0.37) | CREBBPBRD4GSK3BDYRK1AWNT1 | |
| SCHEMBL29471161 | 0.91 | BRD4 (0.37) | CREBBPBRD4GSK3BDYRK1AWNT1 | |
| SCHEMBL24316676 | 0.91 | BRD4 (0.37) | CREBBPBRD4GSK3BDYRK1AWNT1 | |
| SCHEMBL29471198 | 0.87 | GSK3B (0.38) | CREBBPBRD4GSK3BDYRK1AWNT1 | |
| SCHEMBL26548496 | 0.87 | GSK3B (0.38) | CREBBPBRD4GSK3BDYRK1AWNT1 | |
| SCHEMBL24316610 | 0.83 | FGFR1 (0.40) | CREBBPBRD4FGFR1FGFR2FGFR3 | |
| SCHEMBL26113389 | 0.76 | CREBBP (0.36) | CREBBPPIK3CDFGFR3 | |
| SCHEMBL30480849 | 0.76 | CREBBP (0.36) | CREBBPPIK3CDFGFR3 | |
| SCHEMBL24316696 | 0.75 | FGFR1 (0.43) | CREBBPFGFR1FGFR2FGFR3 | |
| SCHEMBL29471176 | 0.75 | FGFR1 (0.43) | CREBBPFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210683-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | Aurigene Oncology Limited (IN) | 2023-07-19 | — | — | EP | disclosed |
| CN-116368128-A | Heterocyclic compounds as CBP/EP300 bromodomain inhibitors | 奥瑞基尼肿瘤有限公司 | 2023-06-30 | — | — | CN | disclosed |
| WO-2022053967-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-03-17 | — | — | WO | disclosed |